Accumulation of endosulfan residues in fish and their predators after aerial spraying for the tsetse fly in Botswana. Endosulfan sulfate reaches maximum concentrations on plant surfaces and in soils 10 to 12 days after application of the parent compound Cassil and Drummond, The principle producers of endosulfan are Excel Industries, Ltd. Endosulfan intoxication-blood glucose, plasma electrolytes, Ca levels and hexokinase in rats. Fate of endosulfan in rats and toxicological considerations of apolar metabolites. Effects of endosulfan on mutagenicity were contradictory.
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Pesticide Biochemistry and Physiology. Endosulfan sulfate is a metabolite of both the A and B endosulfan isomers of the parent compound endosulfan.
The range of acute values for the remaining fresh water invertebrate species was from 10 ppb for the snail Ancylus sp. The advisory concentration for the protection of saltwater aquatic organisms is estimated to be 0. Endosulfan sulfate levels in soil were 2 to 7 times greater than the parent compound 2 to 15 months after application of 0. Two years of dietary exposure for dogs at levels of 3 ppm resulted in no observed toxic effects Goebel et al.
Water Quality Advisory Endosulfan Sulfate
Additionally, 48 hours of oral exposure to rats at Metabolism, storage and excretion of 14C endosulfan in the mouse. Care should be taken in the application of this advisory, with consideration of its derivation, as stated in the attached support document. LD50 values for mice ranged from 6. Because of extremely high and variable doses of endosulfan and high incidences of neoplasms in control rats, the carcinogenicity of endosulfan to rats is uncertain from this study Reuber, Although mortality occurred at ppm after 5 days of exposure by intubation in rats, no inhibition of mitosis or chromosome damage was evident in cells of bone marrow and seminiferous tubules Dikshith and Datta, Endosulfan sulfate was mentioned throughout the document but was not included in criteria development.
Cto on 8-hour time-weighted NO average concentrations in air Inhalation Studies: Beg Mirza, and J. Accumulation, metabolism and effects of organochlorine insecticides on microorganisms.
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Fate of endosulfan in rats and toxicological considerations of apolar metabolites. This advisory recommends the use of endosulfan criteria values in the absence of other data.
The acute values for fishes exposed to endosulfan ranged from 1. It is uncertain from this report whether these algae were exposed to the metabolite cl or indirectly as a result of exposure to the parent compound.
The advisory concentrations should be used with caution, since they are derived from minimal experimental evidence, or in the case of SAR derived values, no data on the specific chemical.
Endosulfan sulfate was the major form of endosulfan in liver, small intestine, visceral fat, and feces of mice tcl endosulfan at 10 ppm for 28 days Deema et al. Endosulfan intoxication-blood glucose, plasma electrolytes, Ca levels clt hexokinase in rats.
A plant surface oxidation product of endosulfan. National Research Council of Canada, Guidelines and methodology used in prepara- tion of health effect assessment chapters of the consent decree water quality criteria documents. Endosulfan sulfate forms in both the presence and absence of ultraviolet radiation; its production is positively correlated with temperature Cassil and Drummond, Properties, effects, residues, and analytics of the insecticide endosulfan.
Production of endosulfan in the United States was 3 million pounds in U. The current freshwater and cl water aquatic life criteria hour average for endosulfan are 0.
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Acute toxicity values reported since for invertebrates ranged from 2. Pharmacology, toxicology, and degradation of endosulfan. Endosulfan is a brown, crystalline solid with a terpene-like odor and the following physiochemical characteristics: Endosulfan sulfate has been found in tissues of both fish and rats as well as cfl soils where it is reported to be more persistent than the parent compound McEwen and Stephenson, Lack of cytogenetic effects in male rats.
A value given g5x protect aquatic life can be derived from no observed effect levels NOELthe lowest concentration found in the data which has been observed to cause acute or chronic toxicity or other experimental data which may be applicable.